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COCAINE HCL
Descriptors Found:
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DeCS
Descriptor
English
:
Cocaine
Descriptor
Spanish
:
Cocaína
Descriptor
Portuguese
:
Cocaína
Synonyms
English
:
Cocaine HCl
Cocaine Hydrochloride
HCl, Cocaine
Hydrochloride, Cocaine
Tree Number:
D02.145.074.722.388
D03.132.889.354
D03.605.084.500.722.388
D03.605.869.388
Definition
English
:
An alkaloid ester extracted from the leaves of
plants
including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful
central nervous system
effects
similar
to the
amphetamines
and is a drug of abuse.
Cocaine
, like
amphetamines
, acts by multiple mechanisms on brain catecholaminergic
neurons
; the mechanism of its reinforcing effects is thought to involve inhibition of
dopamine
uptake.
Indexing Annotation
English
:
cocaine
derivatives =
COCAINE
/analogs;
CRACK COCAINE
is available;
cocaine
addiction =
COCAINE-RELATED DISORDERS
Pharmacological Action:
Anesthetics, Local
Dopamine Uptake Inhibitors
Vasoconstrictor Agents
History Note
English
:
COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
3070
Unique Identifier:
D003042
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS